RCM & Prior Auth AI

AI patient billing and revenue cycle platform focused on the patient responsibility portion of provider revenue, which the company notes has risen from roughly 5 percent of provider revenue in 2010 to about 20 percent today and is projected toward 30 percent by decade end. Billie is the AI billing agent, engaging patients across chat, text, email, and voice to answer billing questions, explain what is owed, and take payment, with the company stating it handles the majority of cases and staff step in for exceptions. The platform covers intelligent statements, personalized outreach, payment plans, card on file, autopay, and refunds, plus an eligibility and benefits agent. Positioning is deliberately complementary rather than displacing: the company frames the EHR as the system of record and itself as the system of action on top of it. Integrated with more than 20 leading EHRs via API or FHIR, with a bidirectional Epic integration listed in Connection Hub on the Epic Showroom as of July 2026. Reported footprint is more than 3,000 healthcare facilities with over $1 billion in patient payments processed. Customer reported results include collections increases in the 75 to 300 percent range and average days to collect as low as 12.6. Holds HIPAA, SOC 2 Type 2, PCI DSS, and HITRUST i1 compliance. Backed by Sapphire Ventures and Y Combinator; CEO and co-founder Levon Brutyan.

AI orchestration platform for provider side revenue cycle, founded 2022 and built around the payer relationship rather than internal workflow alone. The company frames itself as an autonomous intelligence overlay rather than a replacement system of record, continuously monitoring aged accounts receivable, commercial denials, and shifting payer behaviour. Two product lines work together: Adonis Intelligence provides detection, alerting, denial clustering, smart worklists, and analytics, while AI Agents execute, navigating third party payer portals to run real time medical necessity and authorization checks, extracting unstructured clinical notes from the EHR to draft and file appeal letters, and progressing claims to resolution. Reported automation covers more than 70 percent of standard claim statusing and appeals tracking routines with a stated 20 to 30 percent reduction in long term revenue cycle operating spend. Available through the Epic Connection Hub. Mount Sinai Health System is a named customer using the platform to identify and prioritize billing exceptions, and Fox Valley Orthopedics reported recovering nearly $200,000 in denials. The company publishes an annual State of Revenue Cycle Management benchmark report, whose 2026 edition found payer denials and reimbursement pressure had overtaken staffing as the primary threat to revenue performance. More than $95 million raised including a $40 million Series C in March 2026; co-founder and CEO Akash Magoon.

Generative AI for the provider side revenue cycle, formerly Alpha Health. Unified Automation is the platform: a single engine spanning coding, clinical documentation integrity, prior authorization, and claims, designed to sit on top of existing EHR systems rather than replace them. The architectural argument worth understanding is how it differs from robotic process automation. Rather than recording and replaying screen interactions, which break whenever a payer updates a portal, the company trains models on the behaviour of payer portals, EHR interfaces, and clearinghouse connections so they tolerate interface changes. Modules include Coding Optimizer surfacing missed CPT and ICD-10 codes and compliance risks, CDI Optimizer flagging ambiguous diagnoses and missing specificity, Authorization Advisor handling prior authorization submission and payer specific requirement matching, Auth Status and Claim Status polling payer portals and writing results back to the EHR. The company describes an expert in the loop design that autonomously handles high confidence encounters and escalates edge cases to revenue cycle staff. Models are reported as trained on more than 43 million clinical documents. Reported footprint spans more than 650 hospitals and 6,500 outpatient facilities across all 50 states, with a strategic collaboration with Cleveland Clinic announced to launch revenue cycle AI tools. Customer reported results include a 13 percent reduction in accounts receivable days and 300 or more staff hours saved monthly. Headquartered in South San Francisco; more than $200 million raised.

Payment accuracy and integrity for health plans, and the oldest company in this index by founding date: it began in 1989 and its pre payment editing engine is the former ClaimsXten, with over 30 years of rules and policy content behind it. That history matters to the AI question, because the machine learning sits on top of an established rules engine rather than replacing it. Lyric42 is the orchestration platform, coordinating payment decisions across rules, workflows, policy, and payment accuracy products, and designed to let a plan run a multi vendor strategy through one integration to core systems. Replay is the audit automation engine, using AI to prioritize high impact claims and automate DRG validation, coordination of benefits review, and itemized bill analysis, with the company reporting up to 3x productivity and 4x findings for internal audit teams while reducing dependence on external vendors. LyricIQ provides the analytics layer. The stated framing is decision intelligence producing payment decisions that are independent, verified, and explainable, applied before disputes and rework enter the system. Named 2025 Best in KLAS for Pre payment Accuracy and Integrity, and reports serving more than 100 payers. Headquartered in Newtown Square, Pennsylvania.

Patient financial experience platform for hospitals, health systems, and physician groups, covering the part of revenue cycle the patient actually experiences: the bill. Cedar Intelligence is the AI decision engine personalizing billing journeys across channels, and Kora is the voice agent, launched April 2025 and developed with Twilio, trained on the company's proprietary billing data rather than a general model. Kora resolves common billing inquiries on first contact, explaining charges, identifying payment options, and connecting patients to financial assistance, with sentiment and tone detection, multiple language support including Spanish, and escalation to a live agent with full context when human judgment is required. One year in, the company reports Kora has handled nearly 400,000 patient calls across ten provider organizations spanning Epic and Cerner health systems, physician staffing groups, and large specialty groups, with Gastro Health alone accounting for more than 60,000 calls since September 2025. Kora Outbound extends the agent to proactive engagement of harder to reach patients. The company reports its platform data foundation exceeds one billion patient interactions. Its own published research is unusually pointed for a vendor: 40 percent of collectible dollars on its platform now come from uninsured patients, up 54 percent in three years, and it argues that billing experiences designed for financially stable patients are failing those under the greatest strain.

AI utilization management, and the only vendor in this index positioned to sit between payer and provider rather than serving one side. The Dragonfly platform (formerly CORTEX) uses real time predictive analytics to continuously assign an objective medical necessity score, the proprietary Care Level Score, and an anticipated level of care for every patient, with the stated intent of removing subjectivity from patient status determination so both parties work from the same evidence. Product lines cover Utilize for utilization review and case management, Navigate for discharge readiness and length of stay, Advise for physician advisor workflow and peer to peer escalation, and revenue integrity for denials and appeals. Precision UM is the deepest tier, a shared utilization management approach between a health system and a health plan built on common clinical data and historical determination patterns. Integration with the EMR is bidirectional. The company also sells Physician Advisor Services, supplementing night and weekend coverage or operating fully outsourced, so buyers should separate the platform from the staffed service. Named outcome: AnMed reported 14.6x return on investment over a twelve month period and 1,221 hours of front end review time saved through Precision UM with a national health plan. A third party study found Dragonfly rendered clinical review determinations 38 percent faster than fax and 15 percent faster than through the EMR. Headquartered in Franklin, Tennessee; co-founded by Joan Butters.

Prior authorization decision support for health plans and pharmacy benefit managers, the third payer side vendor in this index alongside Cohere Health and Alaffia, and the one weighted toward pharmacy benefit rather than medical. BanjoPA automates the end to end workflow: the CARE engine extracts information from faxed or digital prior authorization requests, validates and maps it to case fields, then matches the case against the payer's own clinical criteria. The distinguishing technical step is that CARE transforms dense clinical guidelines into decision trees, converting narrative coverage policy into an executable structure, and the platform reads prescriber notes directly from the EHR rather than relying on manual data entry or fax and phone follow up. The company states its model matches each request against the specific payer's rules rather than applying generic AI, and that every AI generated recommendation carries detailed evidence and an explanation. BanjoA&G extends the same approach to appeals and grievances. Positioned around CMS-0057-F interoperability and prior authorization compliance. Holds HITRUST r2 certification. Named implementation with Navitus, a large transparent pass through PBM owned by SSM Health and Costco serving over 18 million lives, expanded across employer and health plan lines including Medicare and Medicaid in December 2025. Founded by Saar Mahna.

Healthcare data and agentic AI platform, described by the company as an agentic cloud for healthcare, built in three stages: data connectivity integrating Epic, Cerner, MEDITECH, and Allscripts with payer claims, pharmacy, lab, remote monitoring, and social determinants sources across a reported 80 million plus patient records; applications on top of that data; and now autonomous agents. Gravity is the underlying data platform, continuously trained on real world healthcare data including claims denials and edge cases, which the company argues gives each new agent institutional context at launch. Sara is the AI assistant line spanning insights, care management, and clinical documentation via Sara Scribe. A suite of pretrained voice enabled agents covers appointment scheduling, protocol intake, referral management, routine patient inquiries, prior authorization, care gap closure, hierarchical condition category coding, and transitional care management, supporting clinicians, care managers, risk coders, patient navigators, and contact center staff. The stated architectural claim is end to end workflow connection: a prior authorization agent can hand off to coding and denial management agents rather than each operating in isolation. Reports serving six of the top 10 US health systems and more than 130 healthcare organizations, with named customers including Kaiser Permanente, Ascension, and Trinity Health. Best in KLAS recognition across data and analytics, population health management, and CRM categories. Founded 2014; $675 million raised in total including a $275 million Series F, with investors including Kaiser Permanente and Banner Health.

Clinical intelligence platform sold to health plans, spanning utilization management, payment integrity, appeals, care management, and policy management. The company states it is sold to health plans, and that providers and manufacturers do not license the platform, which makes it payer side alongside Alaffia. Cohere Unify combines a reported 350 or more clinically trained AI models with workflow automation and human review to auto determine prior authorization requests in real time, and Cohere Connect provides the prior authorization APIs, reported to have carried more than 15 million submissions and to support 47 million payer provider interactions annually. The critical design fact is the direction of automation: the company reports up to 85 percent real time approvals and states explicitly that remaining submissions are reviewed by a clinician before final determination, meaning the model approves and humans decide the rest. Additional products include Cohere Review Assist for acute inpatient care, Cohere Policy Studio, and a Payment Integrity Suite extended through the September 2025 acquisition of ZignaAI. Reported outcomes include care access 70 percent faster than traditional processes, up to 9x return on investment, 94 percent provider satisfaction, and a provider NPS of 67. Named plan relationships include Humana and Geisinger. $90 million Series C in May 2025.

AI agent platform for healthcare operations, spanning patient access, revenue cycle, and care operations rather than a single workflow. Agents automate patient intake and registration, appointment scheduling, insurance eligibility verification, prior authorization, denial management, patient payment estimates, referral processing, and post visit follow up, each running a defined workflow end to end. Flow Builder is a no code interface that lets an organization's own IT and non technical staff build, train, and deploy agents, which places it alongside Bunkerhill and XCaliber as a build your own platform rather than a fixed product set. Integration is unusually pragmatic and is the stated differentiator: the company uses whichever method reaches the field, including APIs, RPA, and HL7, reading and writing structured and unstructured data across Epic, Oracle Health, MEDITECH, athenahealth, and payer portals. Named health system deployments include Intermountain, Trinity Health, and MUSC. Published customer results include a health system reaching 64 percent voice containment with roughly $360,000 annual savings, and an insurance FAQ voice assistant answering all inbound calls at a stated $4 saving per call. Backed by Greylock and ICONIQ Growth.

Agentic patient services platform for pharmaceutical manufacturers, automating the post prescription access journey that determines whether a prescribed therapy ever reaches the patient. Named agents handle distinct functions: a consent agent manages opt in for sharing patient health information across manufacturers, specialty pharmacies, and provider hubs; a marketing agent personalizes educational outreach from multi source data; and an enrollment agent accelerates virtual hub enrollment by automating document verification, form completion, and payer navigation around the clock. Ships modular pre configured solutions including automated annual reverification, digital enrollment, bridge to copay sweeps, and click to agent conversational interfaces. The company positions itself as an alternative to traditional labor intensive hub models, where enrollment and reverification are handled by large human teams. Formerly Lifelink Systems, founded 2015; Precision AQ made a strategic investment in 2025 and named an incoming chief executive.

Multi agent platform automating clinical and administrative workflows from a single interface, with a coordinated network of role specific agents: an AI Receptionist handling inbound and outbound calls, scheduling, and patient communication; an AI Medical Assistant running intake, triage, and history capture; an AI Scribe producing real time documentation with ICD-10 and CPT evidence links; AI Coder and Biller agents for coding and revenue cycle; and an AI Inbox Manager working refills, messages, labs, and follow ups. States bidirectional integration with Epic, Cerner, and Allscripts and HIPAA compliance, with paperless intake syncing to the EHR. Marketed on reduced clinical support staff cost and shorter patient wait times, with stated attention to rural and underserved providers. Founded 2023 in Bellevue, Washington; emerged from stealth in late 2025 with a seed round. Early stage, and the breadth of the agent roster should be weighed against how recently the company began selling.

Hub of conversational AI agents for hospitals, operating across three orchestrated layers: triggers, where agents identify clinical gaps and risks from health assessments, prescriptions, and diagnostic findings; navigation, where agents qualify patients and guide care journeys; and revenue, where pending care is converted into booked services. Patients calling or messaging reach conversational AI with no menu and no IVR, and the agent accesses the real schedule to resolve the request end to end. After a visit an agent reads the medical record, identifies prescribed exams and consultations that were never booked, and proactively offers scheduling over WhatsApp, recapturing care that would otherwise be lost to follow up. Other agents confirm appointments with preparation guidance to reduce no shows. WhatsApp as the primary channel reflects the market: the company serves reference hospitals in Brazil and Mexico and is scaling across Latin America, which makes it one of the few vendors in this index built for a non US care and communication context. Pre seed stage; founded by Sergio Ricardo Santos.

AI native revenue operations platform for post acute care providers including home health, hospice, home care, and nursing homes, a segment the larger revenue cycle vendors largely do not serve. Automates the referral to reimbursement cycle across revenue assurance, smart intake, authorization autopilot, billing operations, and platform intelligence. The model identifies upstream data, documentation, and coverage risk inside the EMR to prevent denials before submission, centralizes and auto extracts referrals arriving by fax, email, and portal, automates prior authorizations from submission through renewal, and resolves claims to cash through posting, reconciliation, and prioritized denial follow up. Routine work is automated while exceptions surface to human billers who make the decisions. Voice agents for insurer information requests are in development. Founded 2025 by Kevin Calcado and JJ Ram; $4.4 million seed in January 2026 led by Maverick Ventures with Peak XV, Y Combinator, and executives at large post acute providers participating.

AI native operating system for behavioral health clinics, combining a set of named AI workers with an integrated EHR, CRM, and revenue cycle management in one platform. Sarah, the admissions coordinator, answers inbound calls, texts, and faxes around the clock and verifies insurance in real time, with more than 100,000 patients booked reported. Emma, the clinical assistant, generates ICD-10 and CPT coded session notes within about 30 seconds and is reported to have supported more than 3 million patient sessions. Eric handles coding, claim scrubbing, submission, and denial management. Laura manages between visit engagement. The fully integrated platform launched April 2026, partners with athenahealth through the athenaOne Marketplace, and reports clinics booking 30 percent more patients with clinicians saving more than two hours daily, across hundreds of mid to large behavioral health clinics. Behavioral health operations are a distinct problem from general practice, and the specialization is the point. Backed by Y Combinator, Precursor Ventures, Pioneer Fund, Rebel Fund, and Expansion Venture Capital.

AI revenue integrity platform for specialty physician practices, surgery centers, and health systems, working both sides of the denial problem. To prevent denials it reviews every encounter against coding standards, payer policy, and the practice's own contracts, checking CPT, ICD-10, HCPCS, modifiers, NCCI edits, and documentation completeness, returning suggested corrections that carry the underlying rule and its source from CMS, NCCI, or payer policy rather than an unexplained flag. To recover them it identifies root cause, retrieves records, references payer policy and contract terms, drafts the appeal packet with clinical evidence, and tracks it through adjudication. Also provides ambient scribing across dozens of specialties, benchmarks payer rates to surface underpayments, and tracks payer policy changes. Runs on US based cloud infrastructure stated as HIPAA and SOC 2 compliant. Reports 55 to 57 percent fewer denials and 98 percent coding accuracy for customers. Co founded by a former healthcare AI product manager at Google and a CTO with explainable AI research background at MIT CSAIL; $4.3 million seed in November 2025 led by Nexus Venture Partners with Y Combinator.

AI billing and revenue cycle management for dental practices, combining automation with in house billing staff. Connects directly to practice management systems including Open Dental, automating insurance verification with full benefit breakdowns, clean claim submission with attachments, payment posting within 24 hours, denial appeals using payer specific templates, and accounts receivable follow up tracking claims aging past 30, 60, and 90 days. The distinctive capability is an AI voice agent that calls payers directly when a resubmitted claim shows no update, navigating the phone tree and updating claim status automatically, the same payer facing pattern Prosper AI applies on the medical side. The vendor reports maintaining current contract data across more than 50 major payers, enabling automated eligibility without manual contract uploads. Founded 2023 by Shreyas Parab and Anton Lin; seed stage with AI Grant among investors.

Agentic operating system positioned as a coordination layer across the systems a provider already runs rather than a replacement for them, on the premise that health systems accumulated EHRs, billing platforms, and scheduling tools over two decades without ever acquiring a layer to coordinate between them. Merlin is the role based agent line, and Patient Navigator, the first shipped agent, spans scheduling, prescription refills, outreach, intake, referrals, prior authorization, and billing resolution. The architecture is deliberately semi autonomous: agents run routine administrative workflows end to end and act across silos in real time, while a human in the loop structure keeps teams in control of critical decisions, with the degree of autonomy varying by whether a task is operational or clinical. The platform blends generative AI with traditional machine learning and microservices so deterministic tasks stay deterministic. Reports processing more than 8 million chart updates and generating over 160,000 EHR updates daily across more than 700,000 unique patients, with the navigator agent saving providers an average of six hours of manual work per day on refills alone. EHR integrations include Epic, Cerner, athenahealth, and eClinicalWorks, with listings on the athenahealth and AVIA marketplaces. Led by co founder and CEO Prakash Khot, previously a co founder of Skyflow; $6.5 million seed announced May 2026. Headquarters is reported as Andover, Massachusetts in funding announcements and as Plano, Texas by Crunchbase; this record does not resolve the discrepancy.

Agentic AI for health plan claims operations, and the only payer side vendor in this lane: the buyer is the plan rather than the provider. Covers the full claims lifecycle across payment integrity, utilization management, and appeals. Proprietary optical character recognition digitizes unstructured itemized bills and medical records, agents extract and structure clinical facts and cross reference a claim against the complete patient record, clinical criteria, and policy guidelines, automating routine cases and prioritizing high value claims for human review. A generative assistant helps reviewers summarize records, source guidelines, and draft determination responses. The company states it deliberately avoids black box denial algorithms: every recommendation carries a clinical rationale and traceable citations, and licensed clinicians validate and sign off. Maintains SOC 2 Type II, HIPAA, and HITRUST. Reports saving health plans more than $120 million, over 20 percent average savings on high cost facility claims, and go live in roughly 30 days. Founded 2020 by siblings TJ Ademiluyi and Adun Akanni; $55 million Series B in February 2026 led by Transformation Capital, bringing total funding above $73 million.

Indexed for the AltitudeAI product suite rather than for the underlying revenue cycle platform, which is treated as context under this index's product scoping rule. AltitudeAI, launched January 2025, brings the company's AI capabilities under one brand across a cloud based RCM platform serving a reported one million providers and processing more than six billion transactions annually, reaching roughly half of US patients. AltitudeCreate applies generative AI to autonomously draft appeal letters for denied claims, drawing on a library of more than 1,100 payer specific appeal templates. AltitudePredict uses predictive analytics to score and prioritize denied claims by expected cash value and likelihood of being overturned. AltitudeAssist, in Claim Manager, converts user prompts into automated denial prevention recommendations that fix issues before submission, which the company reports compresses a three day process to roughly three minutes. The company reports early AltitudeAI results of appeal package creation three times faster, saving about 16 minutes per package. Publicly traded (NASDAQ: WAY).

Indexed for the AI products embedded in Elation's primary care platform, not for the electronic health record itself, which is treated as context under this index's product scoping rule. Note Assist is an ambient scribe that transcribes the visit and structures it into the clinician's own note templates natively inside the chart rather than as a bolt on. Actions listens for clinical intent within the note and drafts the resulting work, including prescriptions, lab orders, and referrals. Clinical Insights surfaces conditions, labs, and medications as a contextual summary at the point of care. AI Fast Lane, launched March 2026, applies Smart Coding to suggest diagnosis and procedure codes from the visit note and problem list, routing claims above a confidence threshold straight to submission without manual review. The commercially material fact for buyers is that Elation states its native AI is included at no additional cost with the EHR subscription. The company was named top solution for Small Practice Ambulatory EMR/PM for 1 to 10 physicians in 2026 Best in KLAS, a recognition covering the platform rather than the AI. Founded 2010 by Kyna Fong and her brother.

AI documentation suite pairing an ambient scribe with point of care automation modules, positioned as an operating system rather than a note taker. AutoScribe produces a fully structured note in about twenty seconds, classifying statements into documentation sections with specialty tuned models covering more than 200 specialties including emergency and hospital medicine. The surrounding suite is what distinguishes it: AutoCDI validates notes against ICD-10 and CPT requirements at the point of care with audit trails for revenue cycle teams, AutoAVS generates patient friendly after visit summaries in the patient's language, AutoRefer drafts referral letters, and AutoPrep reads prior charts to prepare a visit agenda. A Chart Awareness platform launched February 2026 grounds notes in the full longitudinal record including prior notes, labs, imaging, medications, and problem lists. Native API integrations with Epic, Oracle Health, and athenahealth. Cleveland Clinic selected Ambience over four rival scribes for a five year deployment; also reported at UCSF, Memorial Hermann, John Muir Health, The Oncology Institute, and GI Alliance. Support is English first, which points the product at large health systems rather than independent practices.

Enterprise ambient AI documentation platform that turns the clinician patient conversation into a structured, billable note inside the EHR. Named Best in KLAS for Ambient AI in both 2025 and 2026, and reported in use at more than 250 health systems including Kaiser Permanente across roughly 25,000 physicians, Mayo Clinic, Johns Hopkins, Duke Health, UPMC, and the VA. The defining technical strength is Epic depth: embedded across Haiku, Canto, and Hyperdrive with bidirectional note sync, plus an athenahealth partnership, covering more than 28 languages and 55+ specialties across outpatient, inpatient, and emergency settings. Linked Evidence maps every part of a generated note back to the source audio so a clinician can verify any sentence against what was actually said before signing. The platform has extended into structured orders, coding context for revenue cycle, and real time prior authorization through a collaboration with Highmark Health and Allegheny Health Network. Founded 2018 by Shiv Rao, a practicing cardiologist, and Zachary Lipton of Carnegie Mellon.

AI voice agents for patient access and revenue cycle telephony. The distinguishing capability is direction: alongside patient facing calls for scheduling, intake, and billing questions, the agents call payers directly, navigating IVR trees, waiting on hold, and speaking with representatives to obtain benefits and prior authorization details when electronic eligibility transactions return incomplete data, then writing structured results back to the EHR or practice management system. Every call is automatically reviewed by AI for accuracy and compliance rather than by manual audit. The vendor reports reaching more than 150,000 healthcare providers and cites roughly three week implementation. Founded 2023; raised a $30 million Series A led by Andreessen Horowitz in 2026, following a $5 million seed.

AI platform for inbound healthcare document and referral operations. RaeLM, the company's proprietary vision language model, reads unstructured inbound material including faxes, scanned forms, and handwritten documents, extracts the clinical and administrative data, and evaluates it against payer criteria to flag likely denials before submission. The vendor reports RaeLM was trained on more than 100 million anonymized healthcare documents, 2.3 billion data fields, and 8,000 sets of payer criteria, and that the platform processes more than 10 million documents a month for over 150 healthcare organizations. Tennr Network gives referring providers, receiving providers, and patients shared referral status visibility. Voice AI for referral phone workflows was added in 2026. Raised $162 million total, including a $101 million Series C led by IVP in June 2025 at a $605 million valuation.

No code AI workflow automation for pharmacy and healthcare operations, with a center of gravity in 340B program compliance. The platform screens 340B eligible claims, uses language models to investigate unstructured EHR data for referral based savings, and automates rebate reporting, Maximum Fair Price reconciliation, intake, and prior authorization. Referral Agent, launched June 2026, is positioned by the company as the first AI agent purpose built for 340B referral capture. The vendor reports customers including Tampa General Hospital, Renown Health, and Salinas Valley Health, more than 100 healthcare organizations on the platform, and customer reported reductions in manual work of up to 97 percent. Founded by Joy Liu, previously an operator at a health system specialty pharmacy company. Raised a $50 million Series B in 2025.

Agentic AI platform for health systems. Carebricks lets clinical and operational teams build, deploy, and govern their own AI agents across clinical, operational, and administrative workflows rather than buying a point solution per use case. Agents in production include coronary calcium detection on routine chest CT, nephrology triage, lung nodule follow up, referral prioritization, prior authorization packet assembly, and registry automation. The company develops its own FDA cleared imaging algorithms that run inside the platform, including algorithms for coronary artery calcium and aortic valve calcium on contrast enhanced non gated chest CT, mitral annular calcification, and bone mineral density. CMS established a national billing code and OPPS payment for algorithmic CAC and AVC analysis on chest CT effective April 1, 2026. In production at Cleveland Clinic, the University of Texas Medical Branch, Intermountain Health, and Mayo Clinic. Founded by Nishith Khandwala, previously a researcher at Stanford's Center for Artificial Intelligence in Medicine and Imaging.

Precision medicine company (NASDAQ: TEM) whose provider software is what this index covers: Next, an AI clinical decision support system that alerts clinicians to patients who may have fallen off care guidelines, backed by a vendor reported 662 patient prospective study across six sites; Hub, a physician platform rebuilt on an agentic architecture including a prior authorization agent; and David, a generative AI clinical assistant deployed directly into the EHR, with Northwestern Medicine as the first health system. Tempus acquired Deep 6 AI in March 2025, adding a precision research platform that applies natural language processing to structured and unstructured EMR data to match patients to clinical trials in near real time and to generate real world evidence. Deep 6 reports real time EMR feeds across more than 30 health systems, an ecosystem of over 1,000 research facilities including 18 academic medical centers and 11 NCI designated cancer centers, and that sites find more than 25 percent more patients than with traditional recruitment; the company notes 92 percent of trial inclusion and exclusion criteria benefit from unstructured data and that 15 to 20 percent of eligible patients are found through unstructured data alone. Outputs are positioned as decision support requiring trial team validation before action. The sequencing and pharma services businesses are context, not indexed products.

General Catalyst backed roll up of Athelas, Augmedix, and Memora Health selling ambient clinical documentation that flows directly into autonomous coding, clinical documentation integrity, and claims automation. The ambient line spans Augmedix Go (AI drafted notes), Assist (AI plus specialist review), and Live (synchronous human documentation), integrates with more than 50 EHRs including Epic, Oracle Health, and MEDITECH, and is reported to power more than 250,000 providers. A January 2025 Vizient contract provides negotiated access for member health systems.