Infinitus Systems vs Waystar (2026)
Two ways to get an answer out of a payer. Waystar works the electronic rails, clearing claims, eligibility and payment transactions for about one million providers, with AltitudeAI adding denial prioritization, drafted appeals and agentic features. Infinitus Systems picks up the phone, with agents that call payers and pharmacy benefit managers and return results as structured data, and it now takes patient and member calls for manufacturers, payors and patient support hubs. For most providers these run in sequence. The electronic transaction answers the routine question, and the phone call handles what comes back incomplete or not at all. Automate the rails first, because they are cheaper, and buy voice for what is left.
- Reaches what the electronic transaction set does not carry, by calling the payer and speaking to a representative.
- Results written back as structured data, with copilots that hand staff a live representative after the hold.
- Built for manufacturers, patient support hubs and payors as well as providers, with Amgen, Accompany Health and Zing Health named.
- The electronic rails at scale: claims, eligibility and payment transactions for about one million providers, with integrations to more than 500 systems.
- AI inside the platform: denial prioritization, drafted appeals, medical necessity summaries and, since 2026, agentic features.
- Attestations stated in a public filing: HITRUST, SOC 2 Type II and PCI DSS Level 1.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. Infinitus Systems and Waystar are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | Infinitus Systems | Waystar |
|---|---|---|
| Primary category | RCM & Prior Auth AI | RCM & Prior Auth AI |
| Founded | 2019 | 2017 |
| Headquarters | San Francisco, California, United States | Lehi, Utah and Louisville, Kentucky |
| Website | infinitus.ai | waystar.com |
Side by Side
Select any grade to read the note behind it.
Product updates
The latest logged changes from each vendor, newest first, each linked to its source.
Infinitus Systems
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Product / capability
Infinitus's payer calling agents can now identify the right pharmacy benefit manager from the BIN and PCN printed on most member ID cards, rather than from a payer ID mapped in advance.
Source
Waystar
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Product / capability
Waystar launched agentic AI capabilities inside its AltitudeAI platform, moving from software that scores and routes work to agents that carry the work out.
Source
Each vendor in one paragraph
Written to be quoted whole. Each paragraph opens the AI Health Index profile of the vendor: what the product is, who buys it and what it does.
Voice AI agent platform for the calls that stand between a patient and a prescribed treatment. Its agents call payers and pharmacy benefit managers to verify benefits and eligibility and follow up on prior authorizations, appeals and claim status, call provider offices to collect missing enrollment information, and return the results as structured data to the workflow that asked; copilots work the phone menu and the hold, then hand a staff member a live representative.
Source: AI Health Index, September 2026
Waystar's AltitudeAI capabilities on its healthcare revenue cycle platform, which clears claims, eligibility and payment transactions for about one million providers and roughly 60 percent of US patients.
Source: AI Health Index, September 2026
Questions buyers ask
How do Infinitus Systems and Waystar work with the EHR?
For Infinitus Systems, the product page says the agents and copilots can be launched from within Epic, Cerner, athenahealth and Salesforce, and call results are returned as structured data to the provider, payer, hub, specialty pharmacy and manufacturer workflows that asked for them rather than left as a transcript.
With Waystar, the Innovation Lab adds FHIR-based prior authorization connectivity for CMS-0057-F. A 2023 third-party survey reports 94 percent of clients satisfied with its EHR integrations. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 25, 2026. No vendor pays for placement.
How are Infinitus Systems and Waystar priced and sold?
In Infinitus Systems' case, the home page claims up to five times return, with no basis.
Waystar's annual report on Form 10-K says contracts generally combine a subscription fee with a volume-based component, sometimes only one; initial terms run two or three years and renew automatically for one-year terms with standard price escalators; billing is monthly; and more than 99 percent of revenue is recurring subscription or predictable volume. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 25, 2026. No vendor pays for placement.
How do Infinitus Systems and Waystar handle patient data?
With Infinitus Systems, the privacy policy, which covers people who speak with the agents, adds that personal data may be used to improve the functionality of the services, which sits uneasily with the contract-purpose commitment.
In Waystar's case, the website privacy policy covers site visitors, keeping web analytics data 24 months and no longer than five years, and says support staff are trained and bound by confidentiality. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 25, 2026. No vendor pays for placement.
Which settings and specialties do Infinitus Systems and Waystar cover?
For Infinitus Systems, the agents verify benefits and eligibility, follow up with payers on prior authorization and claim status, call provider offices for information missing from program enrollments, and check financial assistance and copay eligibility.
With Waystar, the company's filing reports more than 30,000 client organizations and about one million providers, with revenue split roughly 30 percent hospitals and health systems to 70 percent ambulatory and alternate sites. The AI features run across that platform; results specific to them are not broken out by setting. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 25, 2026. No vendor pays for placement.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers.
Both records were reviewed on this site in September 2026. Recording consent for automated payer calls is the calling organization's obligation, and several states require all party consent.
What a payer representative says on a call flows into the revenue cycle as data, so ask how a wrong answer is caught.