Infinitus Systems vs Prosper AI (2026)
Two voice agent companies working both sides of the call. Infinitus Systems began with the payer call: its agents call payers and pharmacy benefit managers about benefits, prior authorizations, appeals and claim status and return the results as structured data. Since 2025 it also takes inbound patient and member calls and runs outbound health risk assessments and adherence check ins, for pharmaceutical manufacturers, payors, providers and patient support hubs. Prosper AI's agents call payers when electronic eligibility comes back incomplete, and also handle patient scheduling, intake and billing questions, for provider organizations. A manufacturer, hub or payor looks at Infinitus. A provider group that wants one voice vendor for payer calls and patient access looks at Prosper.
- Payer and pharmacy benefit manager calls across benefits, prior authorization, appeals and claim status, with results returned as structured data.
- Built for the pharmaceutical and patient support market, with Amgen named and use reported by eight of the ten largest manufacturers.
- A clinical escalation feature that scores patient calls against the Schmidt-Thompson protocol and hands urgent ones to a nurse, staff or 911.
- Payer calls and patient calls on one platform: scheduling, intake and billing questions alongside benefits and prior authorization.
- Every call reviewed by AI for accuracy and compliance, rather than by sampling.
- It names its underlying model provider, and reports implementation in about three weeks.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. Infinitus Systems and Prosper AI are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | Infinitus Systems | Prosper AI |
|---|---|---|
| Primary category | RCM & Prior Auth AI | Patient Voice Agents |
| Founded | 2019 | 2023 |
| Headquarters | San Francisco, California, United States | New York, New York |
| Website | infinitus.ai | getprosper.ai |
Side by Side
Select any grade to read the note behind it.
Product updates
The latest logged changes from each vendor, newest first, each linked to its source.
Infinitus Systems
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Product / capability
Infinitus's payer calling agents can now identify the right pharmacy benefit manager from the BIN and PCN printed on most member ID cards, rather than from a payer ID mapped in advance.
Source
Each vendor in one paragraph
Written to be quoted whole. Each paragraph opens the AI Health Index profile of the vendor: what the product is, who buys it and what it does.
Voice AI agent platform for the calls that stand between a patient and a prescribed treatment. Its agents call payers and pharmacy benefit managers to verify benefits and eligibility and follow up on prior authorizations, appeals and claim status, call provider offices to collect missing enrollment information, and return the results as structured data to the workflow that asked; copilots work the phone menu and the hold, then hand a staff member a live representative.
Source: AI Health Index, August 2026
AI voice agents for patient access and revenue cycle calls. Alongside patient calls for scheduling, intake, refills and billing questions in up to 45 languages, the agents call payers directly, navigating IVR trees and speaking with representatives to obtain benefits and prior authorization details, then write structured results, recordings and transcripts back to the EHR or practice management system (athenahealth, eClinicalWorks, AdvancedMD and Epic named).
Source: AI Health Index, August 2026
Questions buyers ask
How do Infinitus Systems and Prosper AI work with the EHR?
For Infinitus Systems, the product page says the agents and copilots can be launched from within Epic, Cerner, athenahealth and Salesforce, and call results are returned as structured data to the provider, payer, hub, specialty pharmacy and manufacturer workflows that asked for them rather than left as a transcript.
Prosper's FAQ says it integrates with athenahealth, eClinicalWorks, AdvancedMD and Epic through the integration pathways those systems support, and writes back appointment changes, patient and insurance details, benefits verification outcomes, staff notes, recordings and transcripts. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified August 4, 2026. No vendor pays for placement.
How are Infinitus Systems and Prosper AI priced and sold?
In Infinitus Systems' case, the home page claims up to five times return, with no basis.
Prosper sells through enterprise agreements with provider groups and billing organizations and publishes no rate card. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified August 4, 2026. No vendor pays for placement.
How do Infinitus Systems and Prosper AI handle patient data?
With Infinitus Systems, the privacy policy, which covers people who speak with the agents, adds that personal data may be used to improve the functionality of the services, which sits uneasily with the contract-purpose commitment.
Prosper's HIPAA guide states a zero day retention agreement with OpenAI, its model provider, so protected health information sent to the model is not retained there or used for training, and daily backups kept under a 30 day retention policy. What is not stated is how long call recordings and transcripts are kept in Prosper's own environment, or whether any de identification occurs before QA scoring. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified August 4, 2026. No vendor pays for placement.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers.
Prosper AI's record has not yet been reviewed on this site, so its side of this page rests on the build record. Infinitus scores patient calls for urgency, and no clinician decides the calls it scores as not urgent; ask what happens to those.
Both run recorded calls, and several states require all party consent, which is the calling organization's obligation. What a payer representative says flows into the revenue cycle as structured data, so ask each how a wrong answer is caught.