Deep 6 AI vs Paradigm Health (2026)
The two trial matching platforms that health systems most often shortlist, and they differ in what comes with the software. Deep 6 reads the unstructured record, notes, pathology, genomics and laboratory reports, to match patients and sites in real time, covering the lifecycle from feasibility at study design through enrolment. Paradigm deploys inside the provider record system, reasons over full text notes with language models rather than structured prefilters, and crucially pairs the technology with recruitment staff across a large named provider network. That staffing is usually the difference between a match list and an enrolled patient, because most sites do not have anyone free to work the list. Neither publishes the number that matters most, which is how often an eligible patient is never surfaced at all.
- It reads unstructured clinical data across notes, pathology, genomics and laboratory reports to match patients and sites in real time, and it quantifies how much of the decisive information lives in that unstructured half.
- Functional coverage spans the trial lifecycle from cohort building and feasibility at design through to enrolment, so the same platform serves the sponsor and the site.
- Matching is surfaced with proof, and human research staff validate before anyone is approached, which keeps the recruitment decision where it belongs.
- It deploys inside the provider record system and reasons over full text notes with language models rather than structured prefilters, and published a direct comparison making that case.
- The network is specific and verifiable across dozens of states and well over a hundred provider organisations including designated cancer centres.
- It pairs the software with recruitment staff, so a site is not left to convert matches into enrolments alone.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. Deep 6 AI and Paradigm Health are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | Deep 6 AI | Paradigm Health |
|---|---|---|
| Primary category | Clinical Trials AI | Clinical Trials AI |
| Founded | 2016 | 2021 |
| Headquarters | Pasadena, California, United States | Boston, Massachusetts, United States |
| Website | deep6.ai | paradigmhealth.ai |
Side by Side
Each record in one paragraph
Written to be quoted whole. Each paragraph states what the AI Health Index verified about the vendor, with the caveats attached. Generated from this pair’s live capability grades, so it moves when a grade moves.
The AI Health Index awards Deep 6 AI its top capability grade on AI Centrality. Set against Paradigm Health, Deep 6 AI does not grade higher on any scored axis, though the two are level on several axes, including AI Centrality, AI Safety and PHI Stewardship and HIPAA and BAA Posture. Its thinnest published disclosure sits on Model Supply Chain Disclosure and AI Liability and Recourse. Grades reflect evidence the AI Health Index could verify at the last review, so a low grade records disclosure the vendor has not published rather than a capability it has been shown to lack.
Source: AI Health Index, August 2026
The AI Health Index awards Paradigm Health its top capability grade on several axes, including AI Centrality, Autonomy and Oversight Model and Clinical and Operational Evidence. Set against Deep 6 AI, Paradigm Health grades higher on several axes, including Autonomy and Oversight Model, Model and Technology Transparency and Model Supply Chain Disclosure. Grades reflect evidence the AI Health Index could verify at the last review, so a low grade records disclosure the vendor has not published rather than a capability it has been shown to lack.
Source: AI Health Index, August 2026
Questions buyers ask
Should we choose Deep 6 AI or Paradigm Health?
The AI Health Index grades Paradigm Health higher than Deep 6 AI on every axis that separates them, several axes, including Autonomy and Oversight Model, Model and Technology Transparency and Model Supply Chain Disclosure. Deep 6 AI does not grade higher on any scored axis.
Where do Deep 6 AI and Paradigm Health differ most?
The widest separation the AI Health Index records between Deep 6 AI and Paradigm Health is on Clinical and Operational Evidence, where Deep 6 AI grades C and Paradigm Health grades A. That axis sits in the AI Capability group, so it should carry the most weight for a buyer whose binding constraint is how much of the work the model itself is trusted to do.
Where do Deep 6 AI and Paradigm Health grade the same?
The AI Health Index grades Deep 6 AI and Paradigm Health the same on several axes, including AI Centrality, AI Safety and PHI Stewardship and HIPAA and BAA Posture. Neither holds an advantage the index can evidence on those axes, so they should not carry weight in a selection between these two.
What have Deep 6 AI and Paradigm Health not disclosed?
At the last review, at least one of Deep 6 AI and Paradigm Health published thin or absent detail on Model Supply Chain Disclosure and AI Liability and Recourse. The AI Health Index treats an absent disclosure as a gap in the public record rather than a failure of the product, so these are the axes to get in writing during diligence instead of inferring from the grade.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers. The full set for this category is on the Clinical Decision Support page.
Both carry the documentation bias that defines trial matching and neither publishes it: a patient with a thin or fragmented record matches less often regardless of eligibility, and that population overlaps heavily with the one trials already under enrol. The number to demand from both is the false negative rate on eligibility screening, since an eligible patient who never surfaced is invisible in every metric either reports.
Deep 6 publishes no attestation scoped to the platform, no business associate terms and no governance framework. Paradigm publishes no security attestation and nothing on business associate status. Neither publishes pricing.