Clinical Trials AI
D

Deep 6 AI

Precision research platform applying AI and natural language processing to structured and unstructured EMR data, including physician notes, pathology, genomics, and lab reports, to match patients and sites to trial protocols in real time. Connects health systems, treating physicians, sponsors, and CROs in a shared ecosystem covering cohort building, site feasibility, patient recruitment, and real world evidence generation. Reports sites finding more than 25 percent additional patients relative to traditional recruitment.

Acquired in March 2025 by Tempus AI, a company listed on the Nasdaq, for undisclosed consideration; at the time of the transaction the platform was reported to connect more than 750 provider sites, and the acquirer described the attraction as the integration infrastructure. This record covers the Deep 6 platform. Contracting, assurance and governance questions now run to the parent, and a buyer should establish which entity signs and whether the platform has been migrated onto the parent's infrastructure.

AI Health Index verifiedJuly 28, 2026
Compare Deep 6 AI with other vendors
Founded
2016
Headquarters
Pasadena, California, United States
Website
deep6.ai
Categories
clinical-trials-ai, clinical-decision-support, healthcare-admin-automation
Assessment

Capability Axes

An AI Health Index grade measures what a buyer can verify from public sources on the date shown. It is not a rating of how good the product is. A vendor can build an excellent system and grade low on an axis because it publishes nothing an outsider can check. How grades read

AI Capability
AA on AI CentralityThe artificial intelligence is the product. Remove the model and there is nothing left to sell.
Vendor Published

Natural language processing over unstructured clinical data is the whole product and the company quantifies why it matters: it states 92 percent of trial inclusion and exclusion criteria benefit from unstructured data, and that 15 to 20 percent of eligible patients are found through unstructured data alone. Mining physician notes, pathology reports, genomics results, and labs is described as accessing up to 80 percent more patient data than systems relying on coded fields. Without the language models the platform would be a structured query tool that misses most eligible patients.

BB on Autonomy and Oversight ModelThe oversight structure is described and one part is missing, commonly the threshold at which the system stops or what happens after it is wrong.
Vendor Published

The system identifies and surfaces candidates with proof of matching, and human research staff validate and recruit. The company describes a distinct validation step between identification and recruitment, and separately enables treating physicians to refer patients to studies they are eligible for based on targeted study information and matching evidence.

Providing the matching rationale rather than a bare score is what makes both the coordinator validation and the physician referral decision meaningful. No published detail describes confidence thresholds or how borderline matches are handled.

CC on Model and Technology TransparencyThe architecture is described in general terms with nothing identified. Proprietary is asserted rather than explained.
Vendor Published

The approach is described concretely at the data level, covering AI and NLP applied to structured and unstructured EMR data in real time across notes, pathology, genomics, and labs, with quantified claims about how much additional patient data that unlocks. What is not published is model architecture, matching accuracy, or precision and recall figures.

This is a category wide gap: peer reviewed literature has specifically noted that companies in trial matching, naming this one among others, have not published performance data outside small studies or restricted cohort abstracts, which is a fair criticism to record.

DD on Model Supply Chain DisclosureNothing establishes who else sits between a patient record and an answer.
Vendor Published

Nothing identifies any party in the chain: no model or model family, no hosting arrangement and no sub processor list was located in two passes, and no retention or training terms were found beyond a stated commitment that the platform operates within a secure compliant collaborative environment. The word doing the most work there is collaborative, and it is the substance of this record.

The ecosystem model deliberately connects providers, sponsors and contract research organisations, so the product's value proposition is that parties who would not otherwise share data can act on the same picture of a patient population.

Each of those parties has a different relationship to the patient and a different interest in the data: a provider holds it under a treatment relationship, a sponsor wants to find and enrol, and a research organisation operates under contract to the sponsor. Where patient level data flows between them, at what identifiability, and under whose authority is therefore the central question rather than a peripheral one, and nothing published maps it.

The input compounds it, since the platform reads full unstructured records including notes, pathology and genomics rather than a structured extract. Ask what each party in the ecosystem can see at what identifiability, what authority governs each flow, what is retained after a match, and for a sub processor list.

CC on Clinical and Operational EvidenceNamed customers, or vendor reported percentages with no method, denominator or reference standard. Scale of use is recorded here and is not treated as evidence of benefit.
Third Party Estimated

Operational claims are specific but vendor reported, with sites stated to find more than 25 percent more patients than traditional recruitment methods and one referenced study citing recruitment acceleration up to tenfold alongside increased trial population diversity. Named partnerships with oncology development organizations indicate real commercial traction.

The significant caveat is external and worth recording plainly: published academic literature has observed that this company and its peers have not released performance data beyond small studies or restricted abstracts, so independent verification of matching accuracy does not exist publicly.

CC on AI Safety and PHI StewardshipGeneral assurances of privacy and security that do not answer the questions artificial intelligence raises: what is retained, what reaches a model, and what happens to it there.
Vendor Published

The company states the platform operates within a secure HIPAA compliant collaborative environment, which is a direct if brief commitment. The data surface is broad, spanning full unstructured records including notes, pathology, and genomics across health system populations, and the ecosystem model deliberately connects providers, sponsors, and CROs, so where patient level data flows between those parties is the question a buyer should map. No retention or training data terms were located.

Regulatory and Compliance
CC on HIPAA and BAA PostureCompliance is claimed without the underlying document, or the published privacy notice covers the website rather than the service that handles patients.
Vendor Published

HIPAA compliance is stated explicitly for the platform environment. No separate business associate agreement commitment was located, which is what would raise this, particularly given the multi party ecosystem structure where data visibility extends beyond the originating health system.

CC on Security Certifications and Trust CenterControls are described with an outside check behind them, such as independent penetration testing on a stated cadence, but no attestation against a recognised framework.
Vendor Published

Converted from Not Rated. No attestation scoped to this platform and no trust centre was reached across two searches, one of which returned only unrelated companies' trust pages and generic framework explainers, which is a retrieval pattern this index treats as weak evidence rather than none.

The material change since this row was first written is ownership. This platform was acquired in March 2025 by a company listed on a United States exchange. That does two things to this axis and a buyer should hold them apart.

It opens a route. A domestic filer's annual report must carry a cybersecurity governance item describing processes for assessing and managing cybersecurity risk, board oversight and accountable management. That item is the source of graded disclosures elsewhere in this index and it exists here as a matter of law. It was not retrieved in this pass, so this row does not rely on it, and it should be read before anyone does.

It also raises a question the route does not answer. A parent's enterprise cybersecurity disclosure covers the consolidated registrant. It says nothing about whether a platform acquired part way through the period has been brought inside the parent's integrated security programme, which infrastructure it runs on, or whether any attestation names it. This index has repeatedly found assurance published at a parent level that on inspection described one constituent business.

Three things to establish. Which legal entity now contracts. Whether the platform still operates on its original infrastructure or has migrated to the parent's. And whether any attestation names this platform in its scope section, rather than naming the group.

CC on FDA and Regulatory StatusNo device claim is made and the product is scoped accordingly. Most administrative and operational products sit here and are not penalised for it, because this axis grades the appropriateness of the positioning rather than possession of a clearance.
Vendor Published

No FDA pathway applies. Trial matching identifies candidates for research rather than informing diagnosis or treatment. The governing regime is human subjects research oversight, meaning IRB approval, informed consent, and Good Clinical Practice, with the physician referral pathway adding conventional clinical judgment on top.

CC on AI Governance and Bias DisclosureResponsible artificial intelligence is committed to in policy language with no evaluation behind it. Most of the index sits here.
Vendor Published

Converted from Not Rated. No governance framework, model card or bias disclosure was located, and none now appears at the parent that acquired this platform in March 2025 either.

The domain relevant question here is more consequential than the axis usually implies, and it is worth stating precisely because it applies to every trial matching product in this category. The output of this system determines who is offered access to an investigational therapy. The system surfaces candidates by mining the medical record, so it inherits whatever the record contains: who has been seen, who has been coded, whose notes are detailed enough to satisfy an eligibility criterion. Patients with thin documentation are systematically less matchable regardless of their actual eligibility, and thin documentation correlates with the same populations that trials already under enrol. A matching system can therefore increase recruitment volume and reproduce under representation at the same time, and the volume figure will look like success.

Retained from the prior assessment because it identifies the right measurement. A referenced study reports increased diversity in trial populations through identification of underrepresented patient groups, which points in the right direction. It is a volume claim rather than a comparison. What would substantiate it is a published analysis setting the demographic profile of candidates surfaced by the system against that of candidates found by manual screening at the same sites, and no such analysis was located.

That comparison is the single thing that would move this row, and this vendor is unusually well placed to produce it, because the deployments it describes run alongside existing manual screening at academic centres and designated cancer centres.

DD on AI Liability and RecourseNothing published on what happens when the system is wrong.
Peer Reviewed Publication

Two passes located no matching accuracy, no precision or recall figures, no model architecture, no evaluation methodology and no warranty, indemnity or remediation commitment. The absence is documented by outside parties rather than only observed here, which makes it firmer than a retrieval gap: peer reviewed literature has specifically noted that companies in trial matching, naming this one among others, have not published performance data outside small studies or restricted cohort abstracts.

That is a fair criticism to record and it applies across the category rather than singling this vendor out unfairly. What is described is the data level approach, covering language processing applied to structured and unstructured record data in real time across notes, pathology, genomics and laboratory results, with quantified claims about how much additional patient data that unlocks. Volume unlocked is not accuracy achieved.

The failure direction that matters is invisible by construction and worth stating plainly. A patient wrongly matched wastes a screening visit and is caught at consent. A patient who should have matched and did not is never told a trial existed, never appears in any denominator, and generates no artefact anywhere, so a site running this for a year sees the enrolments it produced and never the ones it missed. Ask for recall against a manually reviewed cohort, the false negative rate by tumour type or condition, and what governs a match a clinician disagrees with.

Integration and Deployment
BB on EHR and Interoperability DepthNamed systems with read access or one directional writing, or standards support with named deployments behind it.
Vendor Published

Direct EMR integration is the delivery mechanism, with the platform analyzing structured and unstructured record data in real time rather than working from periodic extracts. Real time operation against live records is the harder engineering problem and is what enables the stated ability to surface matches in minutes. Deployment runs on major cloud infrastructure. No named EHR integrations, certifications, or standards support were enumerated publicly.

CC on Deployment Model and Data ResidencyA single hosted option with location implied rather than committed.
Vendor Published

Described as a cloud based platform deployed on major cloud infrastructure. No tenancy, hosting detail, or data residency terms are published, which matters for an ecosystem model where multiple organizations access a shared environment.

Commercial
CC on Commercial TransparencyNo price is published and the posture is discoverable: a buyer can establish how the product is sold and what drives the cost before contacting the vendor. Most of the index sits here.
Vendor Published

No published pricing. The ecosystem spans health systems, treating physicians, sponsors, and CROs, and as with peers in this category the economics likely flow primarily from the sponsor side while providers host the patients, but nothing about structure or rates is disclosed.

BB on Setting and Specialty CoverageCoverage is named with validation behind part of it.
Vendor Published

Functional coverage is broad across the trial lifecycle, spanning cohort building and feasibility at study design, site and principal investigator selection, patient recruitment, on study data gathering, and real world evidence generation, with an integrated recruitment module beyond identification. Oncology is the evident depth given named partnerships and product positioning, with fibrosis also referenced. Buyers span health systems, treating physicians, sponsors, and CROs.

Comparisons

Compared With

Each comparison carries a written verdict, the buyer conditions that favor each vendor, and a graded side by side. Pairs that cross a category boundary are grouped separately, and their verdicts state where the boundary sits rather than manufacturing a head to head.

Head to head

Vendors the index assesses as direct competitors to Deep 6 AI for the same buyer.

Adjacent comparisons

Products a buyer researches alongside Deep 6 AI that do a different job: a different category, a different layer of the stack, or a specialist scope. These pages exist to settle whether the comparison is real before it settles which one to pick.

Commercial

Pricing

Vendor-published figures are labeled as such. Figures labeled “Estimated” are derived from third-party sources and have not been confirmed by the vendor.

Entry Price Pricing Basis BAA Tier Implementation Source
Contact the vendor
Undisclosed. Ecosystem spans health systems, physicians, sponsors, and CROs across cohort building, feasibility, recruitment, and real world evidence. Not disclosed separately. The company states the platform operates within a secure HIPAA compliant environment. Not disclosed. Deployment requires direct EMR integration for real time analysis of structured and unstructured record data. Vendor Published

No pricing is published. The structural question a buyer should resolve first is the multi party ecosystem: the platform deliberately connects health systems, treating physicians, sponsors, and CROs in a shared environment, so a provider organization should establish what patient level data is visible to sponsors and CROs, at what stage, and who pays for what. As with peers in trial matching, economics likely flow primarily from the sponsor side.