EliseAI vs Hyro (2026)
Both take routine patient requests off the phones with AI agents, for different organizations. EliseAI for Healthcare runs practice operations across voice, text, email and web chat: scheduling and filling cancellations, recall and waitlist calls, intake and insurance, and billing questions with secure payment links. Hyro serves health systems and payers across the call center, website, text and mobile apps: scheduling, provider and location search, refill requests, MyChart password resets and help desk requests, answering from sources the health system approves, with deep EHR integration. Choose EliseAI for a practice's front desk; choose Hyro for a health system's call center and digital channels.
- You run practices rather than a health system call center.
- Cancelled slots should be filled from a waitlist automatically.
- Billing questions should end with a secure payment link.
- Routine requests are swamping a health system call center.
- Answers should come only from sources your health system approves.
- Password resets and help desk requests should be handled too.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. EliseAI and Hyro are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | EliseAI | Hyro |
|---|---|---|
| Primary category | Patient Voice Agents | Patient Voice Agents |
| Founded | Not recorded | 2018 |
| Headquarters | New York, New York | New York, New York |
| Website | eliseai.com | hyro.ai |
Side by Side
Select any grade to read the note behind it.
Each vendor in one paragraph
Written to be quoted whole. Each paragraph opens the AI Health Index profile of the vendor: what the product is, who buys it and what it does.
Conversational AI for healthcare practice operations. Since September 2026 the voice agent runs on OpenAI's GPT-Live-1 full-duplex voice model, with EliseAI as an early design partner. Partnership pages cover athenahealth and eClinicalWorks practices, and the company names customers in dermatology and OB/GYN.
Source: AI Health Index, September 2026
Conversational AI agent platform for health systems and payers, covering the call center, website, text messaging and mobile apps. Agents handle appointment scheduling and management, provider and location search, prescription refill requests and status updates, frequently asked questions answered from sources the health system approves, MyChart password resets and IT help desk requests, handing complex calls to staff.
Source: AI Health Index, September 2026
Questions buyers ask
How are EliseAI and Hyro priced and sold?
For EliseAI, no rate, unit or tier appears.
With Hyro, a public return on investment calculator estimates time and cost savings, and the home page claims a 5.5 times return within six months, but neither shows what the product costs. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
Which settings and specialties do EliseAI and Hyro cover?
In EliseAI's case, the healthcare pages cover women's health, dermatology, ophthalmology, orthopedics and primary care, practices on athenahealth and eClinicalWorks, and channels across voice, text, email and web chat; named results come from dermatology and OB/GYN practices. Healthcare is one of the company's two businesses, alongside property management.
For Hyro, coverage is organized by organization and channel rather than specialty: health systems, federally qualified health centers (sold on multilingual access), children's hospitals and payers (member and agent experience), across calls, websites, text and mobile apps, with an outbound line for ACA and Medicaid coverage renewal outreach. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
How much do EliseAI and Hyro leave to the clinician?
With EliseAI, no rule says which calls go to a person or what the caller hears when no one is available.
In Hyro's case, the responsible AI page says the design will 'eliminate' hallucinations and misleading responses by restricting data sources. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers.
Both records were reviewed on this site in September 2026. Neither publishes a price. EliseAI states that calls are reused to improve its models, and Hyro publishes little about how its own AI is governed.
Ask both what happens to call recordings after the call.