Dyania Health vs HealthKey (2026)
Dyania Health and HealthKey search patient records for potential clinical trial participants, with people confirming eligibility. Dyania combines an internal health system deployment with physician review services; HealthKey emphasizes protocol configured screening for research practices and networks. Dyania's Synapsis AI answers defined clinical questions from structured and unstructured records rather than generating general summaries. Patient Finder runs inside the health system's firewall, and Dyania physicians review results before delivery. Cleveland Clinic also confirmed matches before patient contact and expanded its deployment after work in cancer and cardiovascular disease. Reported screening results concern particular studies, and what happens to eligible patients the system never surfaces is not described. HealthKey applies inclusion and exclusion criteria to EHR fields, notes and faxed documents. Coordinators use evidence linked candidate lists, with near matches separated for judgment. Oregon Urology, Flourish Research and Tekton Research provide examples across different conditions and EHRs. Its case studies distinguish screening and enrollment stages but do not measure all missed eligible patients. Dyania fits health systems wanting chart screening within their own environment with an added physician review layer. HealthKey fits research sites connecting community clinic records to study specific candidate workflows. Both reduce initial chart search work while leaving qualification and patient approach with the research team.
- Patient records should remain inside the health system firewall.
- Physician review is wanted before results reach the customer.
- Screening should answer defined clinical questions across full records.
- A health system plans an enterprise chart review deployment.
- Research spans community clinics and several study protocols.
- Coordinators need evidence linked candidate and near match lists.
- The workflow should support dashboard access and candidate updates.
- Protocol specific screening must work across connected practice EHRs.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. Dyania Health and HealthKey are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | Dyania Health | HealthKey |
|---|---|---|
| Primary category | Clinical Trials AI | Clinical Trials AI |
| Founded | 2019 | Not recorded |
| Headquarters | Jersey City, New Jersey, United States | Austin, Texas |
| Website | dyaniahealth.com | gethealthkey.com |
Side by Side
Select any grade to read the note behind it.
Each vendor in one paragraph
Written to be quoted whole. Each paragraph opens the AI Health Index profile of the vendor: what the product is, who buys it and what it does.
Medical AI company, with offices in Jersey City and Athens, whose Synapsis AI model reads full electronic medical records and answers specific clinical questions from structured and unstructured data rather than writing summaries. It is used for clinical trial prescreening through Patient Finder, observational studies, registry reporting and quality measurement.
Source: AI Health Index, October 2026
HealthKey helps research practices find potential clinical trial participants in their existing patient records. Teams supply a protocol's inclusion and exclusion criteria, and the software applies those criteria across structured EHR fields, clinical notes, and documents such as faxed PDFs.
Source: AI Health Index, October 2026
Questions buyers ask
How are Dyania Health and HealthKey priced and sold?
For Dyania Health, the company says health systems with about 500,000 patients spend more than $5 million a year on staff doing manual chart abstraction, and describes a one-time deployment inside the health system followed by the company's ongoing maintenance and physician review.
With HealthKey, implementation involves connecting the clinic's records and configuring the protocol's inclusion and exclusion logic, with support for research teams reviewing the results. The homepage's $0 upfront offer expired July 31, 2026, so its assigned values for implementation, setup of five trials, and support no longer describe current charges. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified October 15, 2026. No vendor pays for placement.
Which settings and specialties do Dyania Health and HealthKey cover?
In Dyania Health's case, the company describes Synapsis AI as usable across disease areas, with oncology, cardiology and autoimmune conditions named, and across trial prescreening, observational studies, registry population and reporting, therapeutic gap identification and quality measurement, in North America and Europe.
Oregon Urology used HealthKey for the PSMA-DC prostate cancer trial and achieved an enrollment. Flourish screened an obesity study across four Chicago area partner clinics using two EHR systems, with coordinators reviewing the candidate pipeline and two patients enrolling within 25 days. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified October 15, 2026. No vendor pays for placement.
How much do Dyania Health and HealthKey leave to the clinician?
With Dyania Health, the company's physicians review true and false positives and correct remaining hallucinations before results reach the customer, and in the published Cleveland Clinic work the clinic's research staff confirmed each match before patients were approached. The system answers defined clinical questions rather than writing summaries.
In HealthKey's case, the Flourish workflow similarly flagged boundary cases involving BMI, laboratory timing, or ambiguous history for manual review. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified October 15, 2026. No vendor pays for placement.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers. The full set for this category is on the Clinical Trials AI page.
Dyania is based in Jersey City, New Jersey, with an Athens office; HealthKey is based in Austin, Texas. Neither has a public current fee schedule. HealthKey describes patient success fees without defining the operative payment milestone, and its July promotion has expired.