Avo vs OpenEvidence (2026)
Both answer a clinician's question, and they draw on different bodies of evidence. Avo is built on content rather than a model: a library of digitized medical society guidelines and calculators that health systems extend with their own protocols, with DynaMed as a named knowledge partner. Its AI works inside the record, through documented two way integrations with Epic, MEDITECH Expanse, athenahealth and Juno Health. OpenEvidence answers from the current literature under named journal partnerships, free to verified clinicians and paid for by advertising inside the product. The failure modes differ, and that is the useful part. Avo goes wrong when a guideline is superseded and the library has not caught up. OpenEvidence goes wrong when a summary reaches past what its cited source supports.
- Recommendations anchored to named society guidelines and to a health system's own protocols.
- Documented two way integrations with Epic, MEDITECH Expanse, athenahealth and Juno Health, each saying what it reads and writes.
- A stated SOC 2 Type II attestation, shown on every page of its site.
- Answers from the current literature under partnerships with the New England Journal of Medicine, JAMA and Cochrane.
- Independent peer reviewed studies of its answers, where Avo's figures are its own.
- Free use for verified clinicians, with no procurement cycle.
This comparison is published by AI Health Index, an independent research platform that compares healthcare AI vendors objectively. Avo and OpenEvidence are each graded against the same capability taxonomy, from each vendor's own public materials and the regulatory record, under the AI Health Index verification standard. No vendor pays for placement, and no vendor has reviewed this page. How this evidence is graded
Plain facts
| Fact | Avo | OpenEvidence |
|---|---|---|
| Primary category | Clinical Decision Support | Clinical Reference & Evidence |
| Founded | Not recorded | 2021 |
| Headquarters | Not recorded | Miami, Florida |
| Website | avomd.com | openevidence.com |
Side by Side
Select any grade to read the note behind it.
Product updates
The latest logged changes from each vendor, newest first, each linked to its source.
OpenEvidence
-
Product / capability
OpenEvidence added the American Society of Addiction Medicine's clinical guidelines, guidance and implementation resources to the content behind its answers.
Source -
Product / capability
OpenEvidence launched Patient Take-Homes, a new feature allowing clinicians to optionally turn AI-generated answers into educational materials for their patients.
Source -
Clinical evidence
A systematic review published in npj Digital Medicine evaluated 11 studies assessing OpenEvidence's clinical question-answering capabilities.
Source
Each vendor in one paragraph
Written to be quoted whole. Each paragraph opens the AI Health Index profile of the vendor: what the product is, who buys it and what it does.
Avo is a clinician built decision support platform whose foundation is content rather than a model. Avo Pathway is a library of digitized medical society guidelines and calculators, which health systems customize or supplement with their own protocols through a no code builder, and which knowledge publishers embed their intellectual property into; EBSCO's DynaMed is a named knowledge partner.
Source: AI Health Index, September 2026
AI medical search and clinical decision support used at the point of care, free to verified United States and Canadian clinicians and funded by pharmaceutical and medical device advertising shown inside the product, with enterprise deployments embedded in the electronic health record at named health systems. The published model family is Osler for direct answers in seconds, Sackett for a more thorough survey.
Source: AI Health Index, September 2026
Questions buyers ask
How do Avo and OpenEvidence work with the EHR?
For Avo, the integration effort is given as a number, an Epic build stated at under twenty hours, which directly answers the question a chief information officer asks first.
With OpenEvidence, the first party evidence is recent. On 22 September 2026 the company and the University of Texas Medical Branch announced a collaboration putting cited clinical evidence inside the electronic health record, live at UTMB since March 2026, with adoption reported as growing since launch. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
How are Avo and OpenEvidence priced and sold?
In Avo's case, the terms of use disclose actual consumer subscription prices for two specialty applications, at $19.99 a year for one after a thirty day free trial and $9.99 a year for the other after a ninety day trial, with auto renewal terms and cancellation windows stated.
For OpenEvidence, the named health system collaborations announced through 2026 carry no commercial terms. It is also not stated whether free individual use by a health system's clinicians creates any institutional obligation before a contract exists. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
How do Avo and OpenEvidence handle patient data?
With Avo, the privacy notice states that when patient related clinical data are collected to assist clinical decision making, including data collected via electronic health record integrations, that data is processed only in real time and is not stored or saved after processing, and that patient clinical data is not stored, saved or sold.
In OpenEvidence's case, the scope is narrower than it first looks. The exclusion is drawn around protected health information, not around everything a clinician types. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
Which settings and specialties do Avo and OpenEvidence cover?
For Avo, many note templates are offered.
With OpenEvidence, the product now covers the consultation, the encounter through Visits, and patient contact through the Dialer, with an education platform carrying continuing education and maintenance of certification credit added on 28 July 2026. From the AI Health Index, drawn from each vendor's own published materials and the regulatory record, verified September 29, 2026. No vendor pays for placement.
Related comparisons
Other published head to head assessments involving these vendors or their closest peers.
Both records were reviewed on this site in September 2026. Avo publishes no institutional price, and its privacy notice and terms do not mention HIPAA or a business associate agreement. OpenEvidence is free and funded by advertising.
Ask Avo how quickly a superseded guideline leaves its library, and ask OpenEvidence how it checks that a cited source supports the claim made on it.