Generate:Biomedicines described an agent harness its team built with Claude Code to design CAR T cell signaling domains, combining LLM reasoning with computational tools while scientists steered and inspected each design. Over three rounds it produced a 45 amino acid intracellular domain, under a third the length of the clinical 4-1BB and CD3 zeta domain, that raised CAR surface expression and interferon gamma release in primary T cells. The results are in a company hosted preprint that has not been peer reviewed.
Our readIt is one of the first detailed accounts of a general purpose AI coding agent running a protein design program, down to the models used. The harness is internal, so partners cannot use it yet.